Journal: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

Article Title: AIEgen-Based Fluorescent Nanomaterials: Fabrication and Biological Applications

doi: 10.3390/molecules23020419

Figure Lengend Snippet: Different types of AIEgen-based nanomaterials. ( A ) bare AIE NPs [ , ]; ( B ) AIE-Lipid-poly(ethylene glycol) (PEG) NPs [ , ]; ( C ) AIE-BSA NPs ; ( D ) AIE-SiO NPs [ , ]; ( E ) bare AIE NCs ; ( F ) CH 3 NH 3 PbBr 3 nanocrystals ; ( G ) AIE-Chitosan NPs [ , ]; ( H ) AIE-OXE NPs after photo-crosslinking . Reprinted with permission from [ , , , , , , ]. Copyright 2016 the Royal Society of Chemistry, Copyright 2012 Wiley-VCH, Copyright 2012 The Royal Society of Chemistry, Copyright 2017 Wiley-VCH, Copyright 2017 The Royal Society of Chemistry, Copyright 2017 Wiley-VCH, Copyright 2017 The Royal Society of Chemistry and Copyright 2016 Elsevier, respectively.

Article Snippet: A (right panel) shows that the cellular cytoplasm of HeLa cells was easily stained with folate modified AIEgen NPs (9,10-distyrylanthracene entrapped in silica matrixes) [ ].

Techniques:

Journal: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

Article Title: AIEgen-Based Fluorescent Nanomaterials: Fabrication and Biological Applications

doi: 10.3390/molecules23020419

Figure Lengend Snippet: Methods for fabricating functionalized AIEgen-based nanomaterials: ( A ) with pre-modified building matrixes; ( B ) surface modification of the amino groups-decorated AIE/SiO 2 NPs ; ( C ) AIE aggregates can be naturally encapsulated inside the saponin micelles ; ( D ) dual functionalization of the AIE NPs by post-modification ; ( E ) incorporation of magnetic component (e.g., Fe 3 O 4 ) into AIE-SiO 2 NPs .

Article Snippet: A (right panel) shows that the cellular cytoplasm of HeLa cells was easily stained with folate modified AIEgen NPs (9,10-distyrylanthracene entrapped in silica matrixes) [ ].

Techniques: Modification

Journal: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

Article Title: AIEgen-Based Fluorescent Nanomaterials: Fabrication and Biological Applications

doi: 10.3390/molecules23020419

Figure Lengend Snippet: ( A ) Non-targeting cell imaging via organic An18-F127 NPs (left panel) and targeting cancer cell imaging of folate-functionalized AIE-SiO 2 NPs (right panel) ; ( B ) targeted imaging of microtubules in HeLa cells labelled with the Red-AIE-OXE NPs ; ( C ) CLSM and STED imaging of the microtubule structures with Red-AIE-OXE NPs and the corresponding line profile of the position indicated by the arrow heads (i) and (ii) ; ( D ) In vivo two-photon imaging of bone marrow blood vessels (up) and 3TPFI imaging of brain blood vessels (down) of mice treated with AIE NPs ; ( E ) AIEgen-based NPs for non-invasive fluorescence imaging of tumor-bearing mice and the dissected tumors and organs (The white arrows indicate tumor sites and the red circles indicate dissected tumors. 1—Liver, 2—Spleen, 3—Kidney, 4—Heart, 5—Lung, 6—Tumor, 7—Brain, 8—Intestine) . Reprinted with permission from ref. [ , , , , , ], respectively. Copyright 2017 Wiley-VCH, Copyright 2013 The Royal Society of Chemistry, Copyright 2013 The Royal Society of Chemistry, Copyright 2013 Wiley-VCH, Copyright 2017 The Royal Society of Chemistry and Copyright 2016 Elsevier, respectively.

Article Snippet: A (right panel) shows that the cellular cytoplasm of HeLa cells was easily stained with folate modified AIEgen NPs (9,10-distyrylanthracene entrapped in silica matrixes) [ ].

Techniques: Imaging, In Vivo, Fluorescence